[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"article-detail":3},{"lang":4,"article":5,"alternate":20,"related":25,"latest":34},"en",{"id":6,"slug":7,"title":8,"content":9,"summary":10,"thumbnail":11,"metaDescription":12,"metaKeywords":13,"created":14,"modified":15,"author":16,"authorEn":16,"categoryId":17,"commentCount":18,"thumbnailToContent":19},12600,"vitamin-d3-metastatic-colorectal-cancer-sunshine-solaris-trial","Vitamin D3 and Cancer: The SOLARIS Trial Verdict","\u003Cp style=\"margin:0 0 18px;\">For years, the morning routine has been the same for millions of people: a glass of water, one small capsule of vitamin D. The claims have piled up beside it — stronger bones, a calmer immune system, a healthier heart. And the biggest claim of all: vitamin D as cancer protection.\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">In September, a phase 3 trial published in JAMA poured cold water on that final claim.\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">\u003Cstrong>The trial that said no\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">SOLARIS (Alliance A021703) randomized 455 patients with previously untreated metastatic colorectal cancer. Everyone received standard chemotherapy plus bevacizumab. Half also received high-dose vitamin D3; the other half received standard-dose vitamin D3. The question was simple: would the higher dose slow the cancer down?\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">\u003Cimg src=\"\u002Fattachment\u002F20260929\u002Fc2c281d9e5e84961b42f86d715ece86c.webp\" alt=\"SOLARIS trial design — high-dose vitamin D3 added to colorectal cancer chemotherapy\">\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">After a median follow-up of 20 months, the answer was no. Median progression-free survival was 11.8 months with high-dose vitamin D3 versus 10.3 months with standard-dose vitamin D3 — a difference that never reached statistical significance (HR, 0.92; 95% CI, 0.73–1.16; P = .25). Objective response rates (51% vs 44%) and overall survival were equally unmoved. A possible benefit in patients with left-sided tumors remains hypothesis-generating, not proof.\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">\u003Cstrong>Why vitamin D drew so much hope\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">Vitamin D is not an ordinary nutrient. The skin makes it from sunlight, and the liver and kidneys convert it into a steroid hormone that reaches far beyond calcium and bone. Cells across the body carry receptors for it, and laboratory studies have long suggested it can restrain cell growth and shape immunity. That made vitamin D3 a natural candidate for an old drug with new tricks — and a favorite topic in cancer research.\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">\u003Cimg src=\"\u002Fattachment\u002F20260929\u002Fb91a5a15568a44d1a5ca24f4753f8b3b.webp\" alt=\"Vitamin D pathway — sunlight to skin, liver, kidney, then hormone action\">\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">The earlier hope had a name: SUNSHINE. In 2019, that phase 2 trial reported a supportive hazard ratio suggesting high-dose vitamin D3 might extend progression-free survival in metastatic colorectal cancer, with a median of 13.0 months versus 11.0 months. The signal was promising enough to justify the larger, definitive test.\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">\u003Cstrong>Why a phase 3 verdict matters\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">This is why SOLARIS matters. Phase 2 signals are famous for fading in bigger confirmatory trials: patient groups change, controls tighten, and early hope meets statistics. SOLARIS was that confirmatory test, and it did not reproduce the signal. \"Old drug, new use\" is not dead, but it now carries a heavier burden of proof.\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">\u003Cimg src=\"\u002Fattachment\u002F20260929\u002Fc0b68b3a720845fa83f39eb2b49d537a.webp\" alt=\"Evidence ladder — phase 2 signal fading at the phase 3 confirmatory step\">\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">\u003Cstrong>What this means for you\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">None of this means vitamin D is useless. Its established roles — bone health, calcium absorption, correcting deficiency — stand on much firmer evidence. What changed is the story about cancer: one more trial, one more reminder that a supplement is not chemotherapy, and that a good mechanism is not yet a good medicine. Before taking high doses of anything, ask what level of evidence sits behind the claim.\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">\u003Cstrong>See the bone side of the story\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">Vitamin D's most famous job is keeping calcium in your bones — and bone tissue is one of the most beautiful things a microscope can show you. Elastic cartilage, with its glassy matrix and living cells, reveals exactly the kind of tissue that depends on that calcium. Want to look for yourself? WWAI is an AI-powered biology encyclopedia that answers your questions instantly and lets you observe real microscope slide specimens online — including an elastic cartilage specimen where the cartilage cells and matrix are clearly visible. Search \"WWAI\" in your app store and download it today.\u003C\u002Fp>\n\u003Cdiv class=\"dp-template-card\" style=\"border-radius:8px;box-shadow:0 2px 8px rgba(0,0,0,0.1);margin:10px 0;max-width:100%;overflow:hidden;width:100%;\">\n \u003Ca style=\"display:block;text-decoration:none;\" href=\"https:\u002F\u002Fyun-hub.chat\u002Flink\u002F?app=wwai&clickid=stellarx&dplink=specimenid%3D1011\" target=\"_blank\">\u003Cimg class=\"image_resized\" style=\"display:block;height:auto;max-width:100%;width:100%;\" src=\"\u002Fattachment\u002F20260824\u002F5ba5dd3c38404fe785f43c44423830de.png\" alt=\"5ba5dd3c38404fe785f43c44423830de\">\n  \u003Cbutton style=\"align-items:center;background-color:#1f983e;border-radius:0 0 25px 25px;border-style:none;color:#ffffff;cursor:pointer;display:flex;font-family:Times New Roman;font-size:19px;height:40px;justify-content:center;padding:0;width:100%;\">EXPLORE NOW\u003C\u002Fbutton>\u003C\u002Fa>\n\u003C\u002Fdiv>\n\u003Cp style=\"margin:0 0 18px;\">References:\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">[1] SOLARIS randomized clinical trial (Alliance A021703), JAMA 2026. https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F42545685\u002F\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">[2] SUNSHINE phase 2 randomized clinical trial, JAMA 2019. https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F30964527\u002F\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">[3] Dana-Farber Cancer Institute news release on high-dose vitamin D3 in metastatic colorectal cancer. https:\u002F\u002Fwww.dana-farber.org\u002Far\u002Fnewsroom\u002Fnews-releases\u002F2024\u002Fhigh-dose-vitamin-d3-does-not-provide-benefit-for-metastatic-colorectal-cancer\u003C\u002Fp>\n\u003Cp style=\"margin:0 0 18px;\">[4] All illustrations are AI-generated.\u003C\u002Fp>","","\u002Fattachment\u002F20260929\u002Fa59436c903e0404b9c27a13dfa1fb7fd.webp","Does vitamin D3 help colorectal cancer? The SOLARIS phase 3 trial added high-dose vitamin D3 to chemotherapy and found no survival benefit.","stellarx, wwai, vitamin D3, colorectal cancer, SOLARIS trial, progression-free survival","2026-09-29 00:02:00","2026-09-29 11:32:33","Science Guide Wwai",77,0,false,{"id":21,"slug":22,"title":23,"lang":24},12640,"north-vs-south-china-dining-habits2","南北方人吃饭到底有多不一样？从骨碟到饭碗，餐桌习惯差别真不少","zh",{"prev":26,"next":30},{"id":27,"slug":28,"title":29,"categoryId":17},12602,"gallstones-diet-bile-wcsb","Gallstones at 26: What Your Diet Does to Bile",{"id":31,"slug":32,"title":33,"categoryId":17},12595,"rabies-mucosal-transmission","He Never Got Bitten. 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